5-HYDROXYINDOLES IN MENTAL DEFICIENCY

5-Hydroxyindoles in mental deficiency.

During a previous investigation in which a decreased production of 5-hydroxyindoles was demonstrated in phenylketonuric patients (Pare, Sandler, and Stacey, 1957, 1959), we observed that some non-phenylketonuric mental defectives had abnormally high serum levels of 5-hydroxytryptamine (5-HT). We have now extended our observations and tried to define the extent and significance of this finding.

Intraplatelet serotonin and plasma 5-hydroxyindoles in health and disease.

Using a fluorometric test sensitive to serotonin (5-HT) and to other 5-hydroxyindoles (5-HIs) it was shown that platelets take up 5-HT and that the added 5-HT and the inherent test-positive material in platelet lysate can be directly measured. However, platelets do not take up 5-hydroxyindole acetic acid or the 5-HIs from the plasma. Thus, 5-HT and the other 5-HIs can be distinguished. Various ...

5-Methoxy- and 5-hydroxyindoles in the skin of Bufo alvarius.

The skin of Bufo alvarius, a desert toad of Arizona, contains a number of indolealkylamines and their metabolites belonging to the common series of S-hydroxyindolealkylamines and to the unusual series of 5-methoxyindolealkylamines. The most abundant representative of 5-hydroxyindolealkylamines is, as in numerous other toads, bufotenine (up to 3 mg per g dry skin), the most abundant representati...

Mental Deficiency in 1949

Mental Deficiency

should be of particular interest to teachers, including a descriptive account of two types of Special Schools and their contrasting educational methods. In these chapters, Mr. Duncan writes from personal experience, and in discussing Performance Tests he emphasises the " capacity to deal intelligently with things" (as distinct from abstract thoughts and words) which can, by careful training, be...